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Adjusted P values in Swedish

Significant Diseases in different Cohorts
Discovery and Validation All Significant Ob IFG IGT CGI T2D EPIC-Norfolk All Significant T2D HF KD Isarel ACS

Super pathway
Amino Acid Carbohydrate Cofactors and Vitamins Energy Lipid Nucleotide Partially Characterized Molecules Peptide Xenobiotics

Sub pathway

Acetylated Peptides Advanced Glycation End-product Alanine and Aspartate Metabolism Aminosugar Metabolism Androgenic Steroids Ascorbate and Aldarate Metabolism Bacterial/Fungal Benzoate Metabolism Carnitine Metabolism Ceramide PEs Ceramides Chemical Corticosteroids Creatine Metabolism Diacylglycerol Dihydroceramides Dihydrosphingomyelins Dipeptide Drug - Analgesics, Anesthetics Drug - Cardiovascular Drug - Gastrointestinal Drug - Metabolic Drug - Psychoactive Drug - Respiratory Drug - Topical Agents Endocannabinoid Fatty Acid Metabolism (Acyl Carnitine, Dicarboxylate) Fatty Acid Metabolism (Acyl Carnitine, Hydroxy) Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) Fatty Acid Metabolism (Acyl Carnitine, Medium Chain) Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) Fatty Acid Metabolism (Acyl Carnitine, Polyunsaturated) Fatty Acid Metabolism (Acyl Carnitine, Short Chain) Fatty Acid Metabolism (Acyl Choline) Fatty Acid Metabolism (Acyl Glutamine) Fatty Acid Metabolism (Acyl Glycine) Fatty Acid Metabolism (also BCAA Metabolism) Fatty Acid Synthesis Fatty Acid, Amino Fatty Acid, Branched Fatty Acid, Dicarboxylate Fatty Acid, Dihydroxy Fatty Acid, Monohydroxy Food Component/Plant Fructose, Mannose and Galactose Metabolism Gamma-glutamyl Amino Acid Glutamate Metabolism Glutathione Metabolism Glycerolipid Metabolism Glycine, Serine and Threonine Metabolism Glycogen Metabolism Glycolysis, Gluconeogenesis, and Pyruvate Metabolism Guanidino and Acetamido Metabolism Hemoglobin and Porphyrin Metabolism Hexosylceramides (HCER) Histidine Metabolism Ketone Bodies Lactosylceramides (LCER) Leucine, Isoleucine and Valine Metabolism Long Chain Monounsaturated Fatty Acid Long Chain Polyunsaturated Fatty Acid (n3 and n6) Long Chain Saturated Fatty Acid Lysine Metabolism Lysophospholipid Lysoplasmalogen Medium Chain Fatty Acid Methionine, Cysteine, SAM and Taurine Metabolism Mevalonate Metabolism Monoacylglycerol Nicotinate and Nicotinamide Metabolism Oxidative Phosphorylation Pantothenate and CoA Metabolism Partially Characterized Molecules Pentose Metabolism Phenylalanine Metabolism Phosphatidylcholine (PC) Phosphatidylethanolamine (PE) Phosphatidylglycerol (PG) Phosphatidylinositol (PI) Phosphatidylserine (PS) Phospholipid Metabolism Plasmalogen Polyamine Metabolism Pregnenolone Steroids Primary Bile Acid Metabolism Progestin Steroids Purine Metabolism, (Hypo)Xanthine/Inosine containing Purine Metabolism, Adenine containing Purine Metabolism, Guanine containing Pyrimidine Metabolism, Cytidine containing Pyrimidine Metabolism, Orotate containing Pyrimidine Metabolism, Thymine containing Pyrimidine Metabolism, Uracil containing Riboflavin Metabolism Secondary Bile Acid Metabolism Short Chain Fatty Acid Sphingolipid Synthesis Sphingomyelins Sphingosines Sterol TCA Cycle Tobacco Metabolite Tocopherol Metabolism Tryptophan Metabolism Tyrosine Metabolism Urea cycle; Arginine and Proline Metabolism Vitamin A Metabolism Vitamin B6 Metabolism Xanthine Metabolism

Metabolites
Amino Acid 1-carboxyethylisoleucine 1-carboxyethylleucine 1-carboxyethylphenylalanine 1-carboxyethylvaline 1-methyl-5-imidazoleacetate 2,3-dihydroxy-2-methylbutyrate 2,3-dihydroxy-5-methylthio-4-pentenoate (DMTPA)* 2-aminoadipate 2-aminobutyrate 2-hydroxy-3-methylvalerate 2-hydroxybutyrate/2-hydroxyisobutyrate 2-ketocaprylate 2-methylbutyrylcarnitine (C5) 2-methylbutyrylglycine (C5) 2-methylserine 2-oxoarginine* 3-(4-hydroxyphenyl)lactate (HPLA) 3-amino-2-piperidone 3-hydroxy-2-ethylpropionate 3-hydroxyisobutyrate 3-methoxytyramine sulfate 3-methoxytyrosine 3-methyl-2-oxobutyrate 3-methyl-2-oxovalerate 3-methylglutarylcarnitine (2) 3-methylhistidine 4-acetamidobutanoate 4-hydroxyglutamate 4-hydroxyphenylacetate 4-hydroxyphenylacetatoylcarnitine 4-hydroxyphenylpyruvate 4-imidazoleacetate 4-methoxyphenol sulfate 4-methyl-2-oxopentanoate 5-(galactosylhydroxy)-L-lysine 5-hydroxylysine 5-methylthioadenosine (MTA) 5-oxoproline 6-bromotryptophan 6-oxopiperidine-2-carboxylate 8-methoxykynurenate acisoga alanine allo-threonine alpha-hydroxyisocaproate alpha-hydroxyisovalerate alpha-ketobutyrate alpha-ketoglutaramate* anthranilate argininate* arginine asparagine aspartate beta-citrylglutamate beta-hydroxyisovalerate carboxyethyl-GABA C-glycosyltryptophan citramalate citrulline cystathionine cysteine cysteine s-sulfate cysteine sulfinic acid cysteine-glutathione disulfide cysteinylglycine cysteinylglycine disulfide* cystine dimethylarginine (ADMA + SDMA) dimethylglycine dimethylguanidino valeric acid (DMGV)* dopamine 3-O-sulfate dopamine 4-sulfate ethylmalonate formiminoglutamate fructosyllysine gamma-carboxyglutamate gentisate glutamate glutamine glutarylcarnitine (C5-DC) glycine guanidinoacetate guanidinosuccinate histidine homoarginine homovanillate (HVA) hydantoin-5-propionate hydroxyasparagine hydroxy-N6,N6,N6-trimethyllysine* hydroxyproline hypotaurine imidazole lactate imidazole propionate indole-3-carboxylate indoleacetate indolelactate indolepropionate isobutyrylcarnitine (C4) isobutyrylglycine (C4) isoleucine isovalerate (C5) isovalerylcarnitine (C5) isovalerylglycine kynurenate kynurenine lanthionine leucine lysine methionine sulfone methionine sulfoxide methylsuccinate methylsuccinoylcarnitine N,N,N-trimethyl-5-aminovalerate N,N,N-trimethyl-alanylproline betaine (TMAP) N,N-dimethyl-5-aminovalerate N,N-dimethylalanine N2,N5-diacetylornithine N2-acetyl,N6-methyllysine N6,N6,N6-trimethyllysine N6,N6-dimethyllysine N-acetyl-1-methylhistidine* N-acetyl-3-methylhistidine* N-acetylalanine N-acetylaspartate (NAA) N-acetyl-aspartyl-glutamate (NAAG) N-acetylcarnosine N-acetylcitrulline N-acetylglutamate N-acetylglutamine N-acetylglycine N-acetylhistidine N-acetylisoleucine N-acetyl-isoputreanine N-acetylkynurenine (2) N-acetylleucine N-acetylmethionine N-acetylphenylalanine N-acetylputrescine N-acetylthreonine N-acetyltryptophan N-acetyltyrosine N-acetylvaline N-carbamoylalanine N-formylanthranilic acid N-methylproline N-monomethylarginine ornithine p-cresol glucuronide* phenol glucuronide phenol sulfate phenylacetate phenylalanine phenyllactate (PLA) phenylpyruvate picolinate proline prolylhydroxyproline pyroglutamine* S-1-pyrroline-5-carboxylate S-adenosylhomocysteine (SAH) sarcosine serine serotonin S-methylcysteine S-methylcysteine sulfoxide S-methylmethionine taurine threonine thyroxine trans-urocanate tryptophan tyramine O-sulfate tyrosine urea valine vanillactate vanillic alcohol sulfate vanillylmandelate (VMA) xanthurenate Carbohydrate 1,5-anhydroglucitol (1,5-AG) 3-phosphoglycerate arabinose arabitol/xylitol arabonate/xylonate erythronate* fructose galactonate glucose glucuronate glycerate lactate maltose maltotetraose maltotriose mannitol/sorbitol mannose N6-carboxymethyllysine N-acetylglucosamine/N-acetylgalactosamine N-acetylglucosaminylasparagine N-acetylneuraminate pyruvate ribitol ribonate xylose Cofactors and Vitamins 4-oxo-retinoic acid alpha-tocopherol beta-cryptoxanthin bilirubin bilirubin (E,E)* bilirubin (E,Z or Z,E)* biliverdin carotene diol (1) carotene diol (2) carotene diol (3) delta-CEHC FAD gamma-CEHC gamma-tocopherol/beta-tocopherol gulonate* heme I-urobilinogen L-urobilin N1-Methyl-2-pyridone-5-carboxamide N1-Methyl-4-pyridone-3-carboxamide oxalate (ethanedioate) pantothenate (Vitamin B5) pyridoxal pyridoxate quinolinate retinol (Vitamin A) threonate trigonelline (N'-methylnicotinate) Energy aconitate [cis or trans] alpha-ketoglutarate citrate fumarate isocitric lactone malate phosphate succinate succinylcarnitine (C4-DC) Lipid (14 or 15)-methylpalmitate (a17:0 or i17:0) (16 or 17)-methylstearate (a19:0 or i19:0) (R)-3-hydroxybutyrylcarnitine (S)-3-hydroxybutyrylcarnitine 1-(1-enyl-oleoyl)-GPE (P-18:1)* 1-(1-enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4)* 1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2)* 1-(1-enyl-palmitoyl)-2-linoleoyl-GPE (P-16:0/18:2)* 1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1)* 1-(1-enyl-palmitoyl)-2-oleoyl-GPE (P-16:0/18:1)* 1-(1-enyl-palmitoyl)-2-palmitoleoyl-GPC (P-16:0/16:1)* 1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0)* 1-(1-enyl-palmitoyl)-GPC (P-16:0)* 1-(1-enyl-palmitoyl)-GPE (P-16:0)* 1-(1-enyl-stearoyl)-2-arachidonoyl-GPE (P-18:0/20:4)* 1-(1-enyl-stearoyl)-2-linoleoyl-GPE (P-18:0/18:2)* 1-(1-enyl-stearoyl)-2-oleoyl-GPE (P-18:0/18:1) 1-(1-enyl-stearoyl)-GPE (P-18:0)* 1,2-dilinoleoyl-GPC (18:2/18:2) 1,2-dipalmitoyl-GPC (16:0/16:0) 10-heptadecenoate (17:1n7) 10-nonadecenoate (19:1n9) 11beta-hydroxyandrosterone glucuronide 12,13-DiHOME 13-HODE + 9-HODE 16a-hydroxy DHEA 3-sulfate 16-hydroxypalmitate 17alpha-hydroxypregnenolone 3-sulfate 1-arachidonoyl-GPA (20:4) 1-arachidonoyl-GPC* (20:4)* 1-arachidonoyl-GPI* (20:4)* 1-cerotoyl-GPC (26:0)* 1-dihomo-linolenylglycerol (20:3) 1-lignoceroyl-GPC (24:0) 1-linolenoyl-GPC (18:3)* 1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6)* 1-linoleoyl-2-arachidonoyl-GPE (18:2/20:4)* 1-linoleoyl-2-linolenoyl-GPC (18:2/18:3)* 1-linoleoyl-GPA (18:2)* 1-linoleoyl-GPC (18:2) 1-linoleoyl-GPE (18:2)* 1-linoleoyl-GPG (18:2)* 1-linoleoyl-GPI* (18:2)* 1-myristoyl-2-arachidonoyl-GPC (14:0/20:4)* 1-myristoyl-2-palmitoyl-GPC (14:0/16:0) 1-oleoyl-2-docosahexaenoyl-GPC (18:1/22:6)* 1-oleoyl-2-docosahexaenoyl-GPE (18:1/22:6)* 1-oleoyl-2-linoleoyl-GPE (18:1/18:2)* 1-oleoylglycerol (18:1) 1-oleoyl-GPC (18:1) 1-oleoyl-GPE (18:1) 1-oleoyl-GPG (18:1)* 1-oleoyl-GPI (18:1) 1-palmitoleoyl-2-linolenoyl-GPC (16:1/18:3)* 1-palmitoleoylglycerol (16:1)* 1-palmitoleoyl-GPC* (16:1)* 1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6) 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)* 1-palmitoyl-2-arachidonoyl-GPI (16:0/20:4)* 1-palmitoyl-2-dihomo-linolenoyl-GPC (16:0/20:3n3 or 6)* 1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6) 1-palmitoyl-2-docosahexaenoyl-GPE (16:0/22:6)* 1-palmitoyl-2-linoleoyl-GPC (16:0/18:2) 1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) 1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) 1-palmitoyl-2-oleoyl-GPC (16:0/18:1) 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) 1-palmitoyl-2-oleoyl-GPI (16:0/18:1)* 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1)* 1-palmitoyl-2-stearoyl-GPC (16:0/18:0) 1-palmitoyl-GPC (16:0) 1-palmitoyl-GPE (16:0) 1-palmitoyl-GPG (16:0)* 1-palmitoyl-GPI* (16:0) 1-stearoyl-2-arachidonoyl-GPC (18:0/20:4) 1-stearoyl-2-arachidonoyl-GPE (18:0/20:4) 1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) 1-stearoyl-2-arachidonoyl-GPS (18:0/20:4) 1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6)* 1-stearoyl-2-linoleoyl-GPC (18:0/18:2)* 1-stearoyl-2-linoleoyl-GPE (18:0/18:2)* 1-stearoyl-2-oleoyl-GPC (18:0/18:1) 1-stearoyl-2-oleoyl-GPE (18:0/18:1) 1-stearoyl-2-oleoyl-GPG (18:0/18:1) 1-stearoyl-2-oleoyl-GPI (18:0/18:1)* 1-stearoyl-GPC (18:0) 1-stearoyl-GPE (18:0) 1-stearoyl-GPG (18:0) 1-stearoyl-GPI (18:0) 2,4-dihydroxybutyrate 21-hydroxypregnenolone disulfate 2-aminoheptanoate 2-aminooctanoate 2-arachidonoylglycerol (20:4) 2-hydroxyarachidate* 2-hydroxybehenate 2-hydroxydecanoate 2-hydroxyheptanoate* 2-hydroxylaurate 2-hydroxypalmitate 2-hydroxyphytanate* 2-hydroxystearate 2-oleoylglycerol (18:1) 2-palmitoleoyl-GPC* (16:1)* 2-palmitoyl-GPC* (16:0)* 2R,3R-dihydroxybutyrate 2S,3R-dihydroxybutyrate 2-stearoyl-GPE (18:0)* 3,4-dihydroxybutyrate 3,4-methyleneheptanoylcarnitine 3beta-hydroxy-5-cholestenoate 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP) 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (CMPF) 3-hydroxy-3-methylglutarate 3-hydroxyadipate* 3-hydroxybutyrate (BHBA) 3-hydroxybutyroylglycine 3-hydroxydecanoate 3-hydroxyhexanoate 3-hydroxyhexanoylcarnitine (1) 3-hydroxylaurate 3-hydroxymyristate 3-hydroxyoctanoate 3-hydroxyoleate* 3-hydroxyoleoylcarnitine 3-hydroxysebacate 3-hydroxystearate 3-methyladipate 4-cholesten-3-one 4-hydroxy-2-oxoglutaric acid 4-methylhexanoylglutamine 5alpha-androstan-3alpha,17alpha-diol monosulfate 5alpha-androstan-3alpha,17beta-diol 17-glucuronide 5alpha-androstan-3alpha,17beta-diol disulfate 5alpha-androstan-3alpha,17beta-diol monosulfate (1) 5alpha-androstan-3alpha,17beta-diol monosulfate (2) 5alpha-androstan-3beta,17alpha-diol disulfate 5alpha-androstan-3beta,17beta-diol disulfate 5alpha-androstan-3beta,17beta-diol monosulfate (2) 5alpha-pregnan-3beta,20alpha-diol disulfate 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) 5alpha-pregnan-3beta,20beta-diol monosulfate (1) 5alpha-pregnan-diol disulfate 5-dodecenoate (12:1n7) 5-dodecenoylcarnitine (C12:1) 7-HOCA 8-hydroxyoctanoate 9,10-DiHOME 9-hydroxystearate acetoacetate acetylcarnitine (C2) adipoylcarnitine (C6-DC) adrenate (22:4n6) alpha-hydroxycaproate andro steroid monosulfate C19H28O6S (1)* androstenediol (3alpha, 17alpha) monosulfate (2) androstenediol (3alpha, 17alpha) monosulfate (3) androstenediol (3beta,17beta) disulfate (1) androstenediol (3beta,17beta) disulfate (2) androstenediol (3beta,17beta) monosulfate (1) androstenediol (3beta,17beta) monosulfate (2) androsterone glucuronide androsterone sulfate arachidate (20:0) arachidonate (20:4n6) arachidonoylcarnitine (C20:4) arachidonoylcholine arachidoylcarnitine (C20)* azelate (C9-DC) behenoyl dihydrosphingomyelin (d18:0/22:0)* behenoyl sphingomyelin (d18:1/22:0)* behenoylcarnitine (C22)* beta-sitosterol branched chain 14:0 dicarboxylic acid butyrylcarnitine (C4) campesterol caprate (10:0) caproate (6:0) caprylate (8:0) carnitine ceramide (d18:1/14:0, d16:1/16:0)* ceramide (d18:1/17:0, d17:1/18:0)* ceramide (d18:1/20:0, d16:1/22:0, d20:1/18:0)* cerotoylcarnitine (C26)* cholate cholesterol cholic acid glucuronide choline cis-4-decenoate (10:1n6)* corticosterone cortisone cortolone glucuronide (1) dehydroepiandrosterone sulfate (DHEA-S) deoxycarnitine deoxycholate diacylglycerol (16:1/18:2 [2], 16:0/18:3 [1])* dihomolinoleate (20:2n6) dihomolinolenate (20:3n3 or 3n6) dihomo-linolenoyl-choline docosadienoate (22:2n6) docosadioate (C22-DC) docosahexaenoate (DHA; 22:6n3) docosahexaenoylcholine docosapentaenoate (DPA; 22:5n3) docosapentaenoate (n6 DPA; 22:5n6) docosatrienoate (22:3n3) docosatrienoate (22:3n6)* dodecadienoate (12:2)* dodecanedioate (C12) dodecenedioate (C12:1-DC)* eicosanedioate (C20-DC) eicosapentaenoate (EPA; 20:5n3) eicosapentaenoylcholine eicosenedioate (C20:1-DC)* eicosenoate (20:1n9 or 1n11) epiandrosterone sulfate etiocholanolone glucuronide glutarate (C5-DC) glycerol glycerophosphoethanolamine glycerophosphoglycerol glycerophosphoinositol* glycerophosphorylcholine (GPC) glyco-beta-muricholate glycochenodeoxycholate glycochenodeoxycholate 3-sulfate glycochenodeoxycholate glucuronide (1) glycocholate glycocholenate sulfate* glycodeoxycholate glycodeoxycholate 3-sulfate glycodeoxycholate glucuronide (1) glycolithocholate sulfate* glycosyl ceramide (d18:1/20:0, d16:1/22:0)* glycosyl ceramide (d18:1/23:1, d17:1/24:1)* glycosyl ceramide (d18:2/24:1, d18:1/24:2)* glycosyl-N-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2OH))* glycosyl-N-behenoyl-sphingadienine (d18:2/22:0)* glycosyl-N-nervonoyl-sphingosine (d18:1/24:1)* glycosyl-N-palmitoyl-sphingosine (d18:1/16:0) glycosyl-N-stearoyl-sphingosine (d18:1/18:0) glycoursodeoxycholate heneicosapentaenoate (21:5n3) heptenedioate (C7:1-DC)* hexadecadienoate (16:2n6) hexadecanedioate (C16) hexadecenedioate (C16:1-DC)* hexanoylcarnitine (C6) hexanoylglutamine hexanoylglycine (C6) hydroxy-CMPF* hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH)) isoursodeoxycholate lactosyl-N-behenoyl-sphingosine (d18:1/22:0)* lactosyl-N-nervonoyl-sphingosine (d18:1/24:1)* lactosyl-N-palmitoyl-sphingosine (d18:1/16:0) laurate (12:0) lignoceroyl sphingomyelin (d18:1/24:0) lignoceroylcarnitine (C24)* linoleate (18:2n6) linolenate (18:3n3 or 3n6) linolenoylcarnitine (C18:3)* linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]* linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]* linoleoylcarnitine (C18:2)* linoleoylcholine* linoleoyl-docosahexaenoyl-glycerol (18:2/22:6) [1]* linoleoyl-linoleoyl-glycerol (18:2/18:2) [1]* lithocholate sulfate (1) lithocholic acid sulfate (2) maleate malonylcarnitine margarate (17:0) margaroylcarnitine (C17)* myristate (14:0) myristoleate (14:1n5) myristoleoylcarnitine (C14:1)* myristoyl dihydrosphingomyelin (d18:0/14:0)* myristoylcarnitine (C14) N-acetyl-2-aminooctanoate* nisinate (24:6n3) N-oleoyltaurine nonadecanoate (19:0) N-palmitoylglycine N-palmitoyl-heptadecasphingosine (d17:1/16:0)* N-palmitoylserine N-palmitoyl-sphingadienine (d18:2/16:0)* N-palmitoyl-sphinganine (d18:0/16:0) N-palmitoyltaurine N-stearoyl-sphingadienine (d18:2/18:0)* N-stearoyl-sphinganine (d18:0/18:0)* N-stearoyl-sphingosine (d18:1/18:0)* N-stearoyltaurine octadecanedioate (C18) octadecanedioylcarnitine (C18-DC)* octadecenedioate (C18:1-DC) octadecenedioylcarnitine (C18:1-DC)* oleate/vaccenate (18:1) oleoyl ethanolamide oleoyl-arachidonoyl-glycerol (18:1/20:4) [1]* oleoyl-arachidonoyl-glycerol (18:1/20:4) [2]* oleoylcarnitine (C18:1) oleoylcholine oleoyl-linolenoyl-glycerol (18:1/18:3) [2]* oleoyl-linoleoyl-glycerol (18:1/18:2) [1] oleoyl-linoleoyl-glycerol (18:1/18:2) [2] oleoyl-oleoyl-glycerol (18:1/18:1) [1]* oleoyl-oleoyl-glycerol (18:1/18:1) [2]* palmitate (16:0) palmitoleate (16:1n7) palmitoleoylcarnitine (C16:1)* palmitoyl dihydrosphingomyelin (d18:0/16:0)* palmitoyl ethanolamide palmitoyl sphingomyelin (d18:1/16:0) palmitoylcarnitine (C16) palmitoylcholine palmitoyl-linoleoyl-glycerol (16:0/18:2) [1]* palmitoyl-linoleoyl-glycerol (16:0/18:2) [2]* palmitoyl-sphingosine-phosphoethanolamine (d18:1/16:0) pelargonate (9:0) pentadecanoate (15:0) phosphocholine phosphoethanolamine (PE) picolinoylglycine pimelate (C7-DC) pimeloylcarnitine/3-methyladipoylcarnitine (C7-DC) pregnanediol-3-glucuronide pregnen-diol disulfate* pregnenediol sulfate (C21H34O5S)* pregnenetriol disulfate* pregnenetriol sulfate* pristanate propionylcarnitine (C3) propionylglycine (C3) sebacate (C10-DC) sphinganine sphinganine-1-phosphate sphingomyelin (d17:1/14:0, d16:1/15:0)* sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* sphingomyelin (d17:2/16:0, d18:2/15:0)* sphingomyelin (d18:0/18:0, d19:0/17:0)* sphingomyelin (d18:0/20:0, d16:0/22:0)* sphingomyelin (d18:1/14:0, d16:1/16:0)* sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) sphingomyelin (d18:1/18:1, d18:2/18:0) sphingomyelin (d18:1/19:0, d19:1/18:0)* sphingomyelin (d18:1/20:0, d16:1/22:0)* sphingomyelin (d18:1/20:1, d18:2/20:0)* sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)* sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)* sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)* sphingomyelin (d18:1/24:1, d18:2/24:0)* sphingomyelin (d18:1/25:0, d19:0/24:1, d20:1/23:0, d19:1/24:0)* sphingomyelin (d18:2/14:0, d18:1/14:1)* sphingomyelin (d18:2/16:0, d18:1/16:1)* sphingomyelin (d18:2/18:1)* sphingomyelin (d18:2/21:0, d16:2/23:0)* sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)* sphingomyelin (d18:2/23:1)* sphingomyelin (d18:2/24:1, d18:1/24:2)* sphingomyelin (d18:2/24:2)* sphingosine sphingosine 1-phosphate stearate (18:0) stearidonate (18:4n3) stearoyl sphingomyelin (d18:1/18:0) stearoylcarnitine (C18) stearoylcholine* suberate (C8-DC) tauro-beta-muricholate taurochenodeoxycholate taurochenodeoxycholic acid 3-sulfate taurocholate taurocholenate sulfate* taurodeoxycholate taurodeoxycholic acid 3-sulfate taurohyocholate* taurolithocholate taurolithocholate 3-sulfate tauroursodeoxycholate tauroursodeoxycholic acid sulfate (1) tetradecadienedioate (C14:2-DC)* tetradecadienoate (14:2)* tetradecanedioate (C14) tricosanoyl sphingomyelin (d18:1/23:0)* trimethylamine N-oxide undecanedioate (C11-DC) undecanoate (11:0) ursodeoxycholate ursodeoxycholate sulfate (1) valerate (5:0) ximenoylcarnitine (C26:1)* Nucleotide 1-methyladenosine 2'-O-methylcytidine 2'-O-methyluridine 3-(3-amino-3-carboxypropyl)uridine* 3-aminoisobutyrate 3-methylcytidine 3-ureidopropionate 5,6-dihydrothymine 5,6-dihydrouracil 5,6-dihydrouridine 5-methyluridine (ribothymidine) 7-methylguanine adenosine adenosine 3',5'-cyclic monophosphate (cAMP) allantoin beta-alanine cytosine dihydroorotate inosine N1-methylinosine N2,N2-dimethylguanosine N4-acetylcytidine N6-carbamoylthreonyladenosine N-carbamoylaspartate orotate orotidine pseudouridine uracil urate uridine xanthine xanthosine Partially Characterized Molecules glucuronide of C10H18O2 (7)* glucuronide of C10H18O2 (8)* glucuronide of C19H28O4 (1)* glycine conjugate of C10H12O2* glycine conjugate of C10H14O2 (1)* metabolonic lactone sulfate pentose acid* Peptide 4-hydroxyphenylacetylglutamine gamma-glutamyl-alpha-lysine gamma-glutamylcitrulline* gamma-glutamylglutamate gamma-glutamylglutamine gamma-glutamylglycine gamma-glutamylhistidine gamma-glutamylisoleucine* gamma-glutamylleucine gamma-glutamylmethionine gamma-glutamylphenylalanine gamma-glutamylthreonine gamma-glutamyltryptophan gamma-glutamyltyrosine gamma-glutamylvaline isoleucylglycine leucylglycine phenylacetylglutamate phenylacetylglutamine phenylalanylglycine valylglycine Xenobiotics (2,4 or 2,5)-dimethylphenol sulfate 1,2,3-benzenetriol sulfate (2) 1,3,7-trimethylurate 1,3-dimethylurate 1,7-dimethylurate 1H-indole-7-acetic acid 1-methylurate 1-methylxanthine 2,2'-Methylenebis(6-tert-butyl-p-cresol) 2,3-dihydroxyisovalerate 2,6-dihydroxybenzoic acid 2-acetamidophenol sulfate 2-aminophenol sulfate 2-hydroxyacetaminophen sulfate* 2-hydroxyibuprofen 2-keto-3-deoxy-gluconate 2-methoxyacetaminophen glucuronide* 2-methoxyacetaminophen sulfate* 2-piperidinone 3-(3-hydroxyphenyl)propionate 3-(3-hydroxyphenyl)propionate sulfate 3-(cystein-S-yl)acetaminophen* 3-(methylthio)acetaminophen sulfate* 3-(N-acetyl-L-cystein-S-yl) acetaminophen 3,7-dimethylurate 3-acetylphenol sulfate 3-ethylcatechol sulfate (1) 3-formylindole 3-hydroxycotinine glucuronide 3-hydroxyhippurate 3-hydroxyhippurate sulfate 3-hydroxyindolin-2-one sulfate 3-hydroxypyridine sulfate 3-methoxycatechol sulfate (1) 3-methoxycatechol sulfate (2) 3-methyl catechol sulfate (1) 3-methylxanthine 3-phenylpropionate (hydrocinnamate) 4-acetamidophenol 4-acetamidophenylglucuronide 4-acetaminophen sulfate 4-acetylphenyl sulfate 4-ethylcatechol sulfate 4-ethylphenyl sulfate 4-hydroxychlorothalonil 4-hydroxycoumarin 4-hydroxyhippurate 4-methylbenzenesulfonate 4-methylcatechol sulfate 4-vinylguaiacol sulfate 4-vinylphenol sulfate 5-acetylamino-6-amino-3-methyluracil 5-acetylamino-6-formylamino-3-methyluracil 5-hydroxy-2-methylpyridine sulfate 6-hydroxyindole sulfate 7-methylurate 7-methylxanthine acesulfame alliin alpha-hydroxymetoprolol atenolol atorvastatin (lipitor) benzoate beta-guanidinopropanoate bromine caffeic acid sulfate caffeine catechol sulfate cinnamoylglycine citalopram propionate* citalopram/escitalopram cotinine dexpanthenol diclofenac dihydrocaffeate sulfate (2) dihydroferulate dihydroferulic acid sulfate EDTA enalapril ergothioneine erythritol ethyl alpha-glucopyranoside ethyl glucuronide ethylparaben sulfate eugenol sulfate genistein sulfate* gluconate glucuronide of piperine metabolite C17H21NO3 (3)* glucuronide of piperine metabolite C17H21NO3 (4)* glucuronide of piperine metabolite C17H21NO3 (5)* glycyrrhetinate guaiacol sulfate hippurate histidine betaine (hercynine)* homostachydrine* hydrochlorothiazide hydroquinone sulfate hydroxycotinine ibuprofen acyl glucuronide iminodiacetate (IDA) indolin-2-one levulinate (4-oxovalerate) mannonate* metformin methyl glucopyranoside (alpha + beta) methyl-4-hydroxybenzoate sulfate metoprolol metoprolol acid metabolite* N-(2-furoyl)glycine N-acetylalliin naringenin 7-glucuronide N-desmethyl tramadol N-oxalyl glycine (NOG) o-hydroxyatorvastatin omeprazole paraxanthine p-cresol sulfate perfluorooctanoate (PFOA) piperine pseudoephedrine pyrraline quinate saccharin salicylate S-allylcysteine succinimide sulfate of piperine metabolite C16H19NO3 (2)* sulfate of piperine metabolite C16H19NO3 (3)* sulfate of piperine metabolite C18H21NO3 (1)* sulfate of piperine metabolite C18H21NO3 (3)* tartarate tartronate (hydroxymalonate) theanine theobromine theophylline thioproline thymol sulfate trans-3,4-methyleneheptanoate umbelliferone sulfate venlafaxine

MGS with the min/max SHAP value

[Clostridium] cellulosi* [Clostridium] hathewayi [Eubacterium] siraeum [Ruminococcus] gnavus Agathobacter rectalis Alistipes obesi Alistipes putredinis Alistipes shahii Alistipes sp. Angelakisella massiliensis Barnesiella intestinihominis Bifidobacterium adolescentis Bifidobacterium longum Blautia luti Blautia sp. Blautia sp. Marseille-P3087 Blautia wexlerae Brotocaccenecus cirricatena Butyrivibrio sp. Clostridia bacterium Clostridiales bacterium Clostridiales bacterium GWF2_36_10* Clostridiales bacterium Marseille-P2846 Clostridiales bacterium VE202-28 Clostridium sp. Clostridium sp. TM06-18 Coprococcus eutactus Coriobacteriia bacterium Enterocloster bolteae Enterocloster hominis Enterocloster lavalensis Eubacteriaceae bacterium CHKCI005* Eubacterium sp.* Faecalibacillus faecis Faecalibacterium prausnitzii Faecalibacterium sp. Flavonifractor sp. Fournierella massiliensis Hominifimenecus microfluidus Huintestinicola butyrica Intestinimonas massiliensis Lachnoclostridium sp. SNUG30386 Lachnospira pectinoschiza Lachnospiraceae bacterium Lawsonibacter sp. Merdibacter massiliensis Monoglobus pectinilyticus Negativibacillus massiliensis Oscillibacter sp. Oscillibacter sp. ER4 Pseudoflavonifractor sp. Pseudoflavonifractor sp. An184 Pseudoflavonifractor sp. An85 Robinsoniella peoriensis Romboutsia timonensis Roseburia faecis Roseburia inulinivorans Roseburia sp. Roseburia zhanii Ruminococcaceae bacterium Ruminococcus sp.* Ruminococcus torques Subdoligranulum sp.* uncultured Enterocloster sp. uncultured Gemmiger sp.